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Primary care
Comparative effectiveness of combination treatment for hypertension in black Africans
  1. Igho Onakpoya
  1. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
  1. Correspondence to Dr Igho Onakpoya, Nuffield Department of Primary Care Health Sciences, University of Oxford, OX2 6GG, UK; igho.onakpoya{at}phc.ox.ac.uk

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Although different combination therapies are currently used for treating hypertension among blacks, the authors of a recently published trial suggest amlodipine plus either hydrochlorothiazide or perindopril is a more effective combination.

Calcium channel blockers are usually recommended as first-line treatment for control of hypertension.1 Among blacks, one or more antihypertensive medications are added to calcium channel blockers when sole treatment is inadequate for blood pressure control. However, there is uncertainty about which drug combination is more effective for use as combination therapy. In the UK for instance, the National Institute for Health and Care Excellence recommends use of either an ACE inhibitor, an angiotensin receptor blocker (ARB), or a …

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