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Primary care
C reactive protein testing to guide antibiotic therapy for COPD exacerbations
  1. Annette Pluddemann
  1. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
  1. Correspondence to Dr Annette Pluddemann, Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK; annette.pluddemann{at}phc.ox.ac.uk

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A recent trial analysed the use of C reactive protein testing in guiding prescribing of antibiotics for exacerbations of chronic obstructive pulmonary disease in primary care.

EBM Verdict

EBM Verdict on: C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations. N Engl J Med 2019;381:111–120. doi: 10.1056/NEJMoa1803185.

  • Using point-of-care C reactive protein tests in primary care to guide antibiotic prescribing for chronic obstructive pulmonary disease exacerbations significantly reduces antibiotic use. Implementation should consider feasibility and practicality, who might do the test and how testing affects the overall clinical decision pathway.

C reactive protein (CRP) is a non-specific marker secreted in response to infectious and inflammatory triggers, and levels are typically highest in patients with a bacterial …

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