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Maternal and child health
Maternal caffeine consumption and pregnancy outcomes: a narrative review with implications for advice to mothers and mothers-to-be
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  • Published on:
    It remains unclear whether caffeine causes adverse pregnancy outcomes; but naive policy recommendations could cause harm.
    • Clare Murphy, Director of External Affairs and Principal Investigator British Pregnancy Advisory Service and The WRISK Project
    • Other Contributors:
      • Tracey Brown, Director
      • Heather Trickey, Research Fellow
      • Julia Sanders, Professor of Clinical Nursing and Midwifery
      • Rebecca Blaylock, Research and Engagement Lead
      • Caitlin Dean, Chairperson
      • Marita Hennessy, Postdoctoral Researcher
      • Laura Schellas, Doctoral Researcher
      • Fiona Woollard, Professor in Philosophy
      • Gemma Sharp, Senior Lecturer in Epidemiology
      • Luisa Zuccolo, Senior Lecturer in Epidemiology
      • Marcus Munafò, Professor of Biological Psychology
      • Kathleen Cairns, General Practitioner
      • Maria Booker, Programmes Director
      • Peter Tennant, University Academic Fellow in Health Data Science
      • Jane Fisher, Director
      • Ellie Lee, Director and Professor
      • Erin Williams, Senior Lecturer in Reproductive Anatomy and Physiology
      • Elizabeth Duff, Senior Policy Adviser
      • Irene Petersen, Professor of Epidemiology and Health Informatics
      • Amber Marshall, Founder

    In his narrative review of the association between maternal caffeine consumption and pregnancy outcomes, Professor Jack E James claimed there was sufficient evidence of harmful causal effects to suggest that pregnant women or women contemplating pregnancy should 'avoid caffeine' (1). His opinions were widely reported by the media in line with a sensational press release that claimed there was "No safe level of caffeine consumption for pregnant women and would-be mothers". We do not however consider these claims to be appropriate or justified, due to a number of serious methodological limitations, statistical errors, and a concerning lack of objectivity. The author declared no conflicts of interest, yet has written extensively on the 'lethality' of caffeine (2). For this, and the following reasons, we believe the review and its recommendations should be interpreted with extreme caution.

    1. Scientific conduct
    a) The article is described as a ‘narrative review’, and thus by its nature, falls well short of the standards expected for a formal systematic scientific review of the literature. It is not clear how the author identified articles for inclusion, nor what criteria were used for exclusion, or what approach, if any, was used to critically appraise the studies identified or synthesise the information obtained. It is therefore difficult to have confidence that the articles presented offer an unbiased reflection of the literature an...

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    Conflict of Interest:
    None declared.
  • Published on:
    Is this evidence enough to change our medical advice to coffee-consumer pregnant mothers?

    In my daily practice that is limited, I've been allowing my patients to drink two cups of coffee a day, although they tend to be restrictive when applying my advice. Most of them are healthy women in their 30s. Whenever they've had a bad result, it has been attributed to other causes. When reading your impeccable research work, I've missed some comment on the clinical relevance of certain outcomes as a minor change in birth weight; moreover, aging or prior medical history may act as confounders of negative pregnancy outcomes. I appreciate your effort very much, but I consider the change of medical recommendations requires a more in-depth assessment, by means of one or more randomized clinical trials. Let's bear in mind than in my home country, Spain, temperatures in summer may be unbearable if you are an active working mother-to-be. And, definitely, our medical role is to give evidence-based solutions and avoid changing our pieces of advice every couple of years.

    Conflict of Interest:
    None declared.
  • Published on:
    Bias in reporting
    • Shavi Fernando, Obstetrician and Gynaecologist, Senior Lecturer, PhD The Ritchie Centre, Monash University, Department of Obstetrics and Gynaecology, Melbourne Australia

    ‘There is no safe level of caffeine intake in pregnancy’. That is the conclusion of this ‘narrative review’ of caffeine safety in pregnancy (BMJ Evidence Based Medicine, Open Access) which a patient brought to my attention very recently after hearing about it on the mainstream media. I felt that it requires clarification to avoid concern amongst the general public and those unable to analyse and critically appraise the literature.

    The single author concluded that, after finding 48 studies (37 observational studies and 11 meta-analyses), caffeine intake in pregnancy significantly increases the risk of miscarriage, stillbirth, low birth weight, childhood leukaemia and childhood overweight/obesity. The author then goes on to recommend that all worldwide guidelines (including American, UK and Australian) stating the safety of caffeine in doses<200mg/day (approximately 2 cups of coffee) should be revised to say ‘there is no safe level of caffeine in pregnancy’.

    However, there is no need to panic, which appears to be the response of the mainstream media and patients from the general population. Very soon after publication, this paper was picked up by several news outlets including CNN, The Guardian and also on a number of social media streams. Women were being told not to drink coffee in pregnancy the same way they were being told not to drink alochol.

    This paper is far from as conclusive as it tries to make the reader believe, but serves as a good exampl...

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    Conflict of Interest:
    None declared.
  • Published on:
    Insufficiently Robust Methodology and risk of bias
    • Raymond F O'Connor, General Practitioner; Senior Research Fellow University of Limerick Medical School

    Editor,
    I welcome this publication with it's focus on a potentially important cause of adverse pregnancy outcomes.
    This study has several methodological faults that need to be declared and addressed.
    The study's single author has written extensively on this topic over the last 29 years. He cites several of his own publications in the paper, As far as I can judge, they are all critical of caffeine in pregnancy. Surely this puts him at risk of bias.
    The best way to address such bias is to conduct a systematic review with precise methodology. Also, at least one other author should be involved in assessing suitability of the papers, and minimising bias.
    Only English language papers are studied.
    Only PubMed and Google Scholar are searched. No reference is made to other important databases such as CDSR, Medline, EMBASE and CINAHL.. There does not appear to have been any pre-specified eligibility criteria in assessing whether or not studies should be included in the review e.g. community based populations or pre defined study methods.
    There is no attempt made to assess the quality of the studies used in writing the paper.
    The search strategy appears vague.
    The results in table 1 give odds ratio but there is no quantification of this. What we need is absolute risk with numbers needed to harm. If this figure cannot be calculated then we should be told and given the reasons why.

    These limitations need to be ackno...

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    Conflict of Interest:
    None declared.