Footnotes

• Twitter @julian_hong

• Contributors MG and JH drafted the manuscript and all authors provided critical revisions. All authors provided final approval of the manuscript and agree to be accountable for all aspects of the work.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests JH is coinventor on a pending patent unrelated to this manuscript. FYF has paid consultant/advisory board relationships with Janssen, Sanofi, Astellas, Bayer, Genentech, EMD Serono, Clovis and Celgene, and an unpaid consultant/advisory board relationship with PFS Genomics.

• Provenance and peer review Commissioned; internally peer reviewed.