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Q In patients with diabetic nephropathy, what are the effects of angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists (AIIRAs)?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Nephrology ★★★★★☆☆ Endocrine ★★★★★★☆
METHODS
Data sources:
Medline (1966 to September 2003), EMBASE/Excerpta Medica (1988 to September 2003), the Cochrane Library, conference proceedings, and contact with experts.
Study selection and assessment:
randomised controlled trials (RCTs) in any language of ⩾6 months’ duration comparing ACE inhibitors or AIIRAs with placebo, no treatment, or each other in patients with any stage of diabetic nephropathy. Studies were assessed for methodological quality.
Outcomes:
all cause mortality …
Footnotes
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For correspondence: Dr G F Strippoli, University of Sydney, New South Wales, Australia. gfmstrippolialiceposta.it
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Sources of funding: Australia-Europe Scholarship; NHMRC Centre for Clinical Research Excellence Grant; Italian Society of Nephrology.