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Aetiology
Perinatal environmental factors and parental psychopathology were associated with risk of autism in Danish children

https://doi.org/10.1136/ebm.10.6.184

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    Larsson HJ, Eaton WW, Madsen KM, et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol 2005;161:916–25.
    OpenUrlAbstract/FREE Full Text

    
 
 Q In Danish children, are perinatal factors and parental psychiatric history and social economic status associated with subsequent development of autism?

    Clinical impact ratings GP/FP/Mental Health ★★★★★☆☆ Paediatrics ★★★★★★☆ Psychiatry ★★★★★★★

    METHODS

    Embedded ImageDesign:

    a case control study nested within a cohort of all children born in Denmark after 1972.

    Embedded ImageSetting:

    Denmark

    Embedded ImagePatients:

    698 children (76% boys, mean age at diagnosis 7.7 y) who were discharged from a Danish psychiatric hospital with a diagnosis of infantile or atypical autism before the end of December 1999 constituted the cases. For each case, 25 controls (total n = 17 450) were identified and individually matched to the cases by sex, birth year, and age in days.

    Embedded ImageRisk factors:

    perinatal risk factors including delivery and newborn characteristics (eg, fetal …

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    Footnotes

    • For correspondence: Dr W W Eaton, Johns Hopkins University, Baltimore, MD, USA. weaton{at}jhsph.edu

    • Sources of funding: Centers for Disease Control and Prevention; March of Dimes Birth Defects Foundation; Stanley Medical Research Institute; National Institute of Mental Health.