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Therapeutics
Oestrogen did not improve health related quality of life in postmenopausal women with hysterectomy

https://doi.org/10.1136/ebm.11.3.76

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    Brunner RL, Gass M, Aragaki A, et al. Effects of conjugated equine estrogen on health-related quality of life in postmenopausal women with hysterectomy: results from the Women’s Health Initiative randomized clinical trial. Arch Intern Med 2005;165:1976–86.
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 Q In postmenopausal women with prior hysterectomy, does conjugated equine oestrogen (CEE) improve health related quality of life (HRQOL)?

    Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Gynaecology ★★★★★★☆ Endocrine ★★★★★☆☆

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial (Women’s Health Initiative [WHI]).

    Embedded ImageAllocation:

    {concealed*}†.

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, {data collectors, and outcome assessors}†).*

    Embedded ImageFollow up period:

    1 year.

    Embedded ImageSetting:

    {40 US clinical centres}‡.

    Embedded ImagePatients:

    10 739 postmenopausal women aged 50–79 years (mean age 64 y, 75% white) with prior hysterectomy. Exclusion criteria included probable survival <3 years and breast cancer. 17% of women had moderate to severe vasomotor symptoms.

    Embedded ImageIntervention:

    oral CEE 0.625 mg/day (n = 5310) or placebo (n = 5429).

    Embedded ImageOutcomes:

    HRQOL (RAND36, 36 items, 8 subscales, range for each subscale …

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    Footnotes

    • ↵* See glossary

    • ↵† Information obtained from G. Anderson, WHI Investigators.

    • ↵‡ Information obtained from

      Anderson G, Limacher M, Assaf AR, et al. JAMA. 2004;291:1701–12
      OpenUrlCrossRefPubMedWeb of Science
      .

    • For correspondence: Dr R L Brunner, University of Nevada School of Medicine, Reno, NV, USA. bbrunner{at}whi.org

    • Source of funding: National Heart, Lung, and Blood Institute.

    Linked Articles

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2006; 11 95a-95a Published Online First: 30 May 2006. doi: 10.1136/ebm.11.3.95a