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  • Inhaled budesonide plus oral prednisone reduced relapse after discharge from the emergency department for acute asthma

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Therapeutics
Inhaled budesonide plus oral prednisone reduced relapse after discharge from the emergency department for acute asthma

https://doi.org/10.1136/ebm.5.1.17

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    (1999) JAMA 281, 2119. Rowe BH, Bota GW, Fabris L, et al.. Inhaled budesonide in addition to oral corticosteroids to prevent asthma relapse following discharge from the emergency department. A randomized controlled trial.. Jun 9;. :. –26.
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 QUESTION: In patients discharged from the emergency department (ED) with acute asthma, does the addition of inhaled budesonide to a fixed dose of oral prednisone reduce relapses?

    Design

    Randomised (allocation concealed*), blinded (patients and outcome assessors),* placebo-controlled trial with 21-day follow-up.

    Setting

    A community hospital ED in Sudbury, Ontario, Canada.

    Patients

    191 patients 16–60 years of age who were treated in the ED for acute asthma and had a peak expiratory flow rate <80% predicted for sex, age, and height. Patients were excluded if they had received oral or inhaled corticosteroids during the previous week. Follow-up was 94%.

    Intervention

    All patients were given a non-tapering, 7-day course of oral prednisone, 50 mg/day, at discharge. 94 patients were allocated to an inhaled budesonide …

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    Footnotes

    • Sources of funding: Physician Services Incorporated Foundation and Sudbury General Hospital Emergency Trauma Fund. Inhalers were supplied by Astra Pharma, Inc.

    • For correspondence: Dr B H Rowe, Division of Emergency Medicine, University of Alberta, Room 1G1.63 WMC, 8440-112 Street, Edmonton, Alberta T6G 2B7, Canada. FAX 780-407-3314.

    • ↵* See glossary.