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Review: palliative chemotherapy reduces death and progression at 12 months in advanced or metastatic colorectal cancer

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 QUESTION: In patients with locally advanced or meta-static colorectal cancer, what are the benefits and harms of palliative chemotherapy?

Data sources

Studies were identified by searching Medline, EMBASE/Excerpta Medica, CancerLit, the Cochrane Controlled Trials Register, CINAHL, HealthSTAR, Science Citation Index, Edina Biosis, NHS Economic Evaluation Database, Index to Scientific and Technical Proceedings, and PASCAL (to October 1998); handsearching conference abstracts; scanning bibliographies of relevant studies; searching sources of unpublished trials; and contacting authors.

Study selection

Studies in any language were selected if they were randomised controlled trials (RCTs) that compared palliative chemotherapy with supportive care alone in patients with advanced or metastatic colorectal cancer.

Data extraction

The quality of studies was …

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Footnotes

  • Source of funding: NHS National Cancer Research & Development Programme UK.

  • For correspondence: Dr L Y Best, CRX Wessex Medical Oncology Unit, Southampton General Hospital, Level F (809), Centre Block, Southampton SO16 6YD, UK. Fax +44 (0)1703 783839.