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  • Fibre supplementation increased the risk for recurrent adenomas, and calcium supplementation did not prevent recurrence

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Therapeutics
Fibre supplementation increased the risk for recurrent adenomas, and calcium supplementation did not prevent recurrence

https://doi.org/10.1136/ebm.6.3.90

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    (2000) Lancet 356, 1300. Bonithon–Kopp C, Kronborg O, Giacosa A, et al. , for the European Cancer Prevention Organisation Study Group.. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial.. Oct 14;. :. –6.
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 QUESTION: In patients with colorectal adenomas, does supplementation with ispaghula husk or calcium prevent adenoma recurrence?

    Design

    Randomised (allocation concealed*), blinded (patients, clinical staff, and investigators),* placebo controlled trial with 3 years follow up.

    Setting

    21 centres in 10 countries (Belgium, Denmark, France, Germany, Ireland, Israel, Italy, Portugal, Spain, and the UK).

    Patients

    665 patients who were 35–75 years of age, had a complete index colonoscopy showing ≥2 adenomas or 1 adenoma of >5 mm in diameter, and did not have a debilitating or life threatening disease. Exclusion criteria were history of large bowel disease, contraindications to calcium or fibre, or inability or unwillingness to stop current fibre or calcium supplementation. 552 patients (83%, mean age 59 y, 64% men) …

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    Footnotes

    • Sources of funding: Europe Against Cancer Programme; Association Centre le Cancer; Association Luxembourgeoise Centre le Cancer; INSERM; French Ministry of Health; Deutsches Krebsforschungzentrum; Danish Cancer Society; FISS; Hospital supplies (Ireland); University of Coimbra; Istituto Tumori Genova.

    • For correspondence: Professor J Faivre, Registre Bourguignon des Tumeurs Digestives, Faculté de Médecine de Dijon, BP 87900, 21079 Dijon, France. Fax + 33 380 66 8251.

    • ↵* See glossary.

    • ↵† p Value calculated from data in article.