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Aetiology
Review: usual blood pressure is directly related to vascular mortality throughout middle and old age

https://doi.org/10.1136/ebm.8.4.122

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    (2002) Lancet 360, 1903. Lewington S, Clarke R, Qizilbash N, et al, for the Prospective Studies Collaboration.. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.. ;. :. −13..
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 QUESTION: In adults with no history of vascular disease, what is the age specific association between usual blood pressure and vascular mortality?

    Data sources

    Studies were identified through searches of Medline and EMBASE/Excerpta Medica, hand searches of meeting extracts, and discussions with investigators.

    Study selection

    Prospective observational studies were included that reported data on blood pressure at baseline and cause and date of death. Studies that deliberately recruited patients with a history of stroke or heart disease were excluded.

    Data extraction

    Reviewers contacted investigators of selected studies to obtain individual patient data. People with a history of stroke or heart disease at baseline were excluded from the analysis. Individual data were used to estimate the main risk factor of interest: usual (ie, long term) blood pressure. Meta-analysis was used to relate mortality during each decade of death to the estimated usual blood pressure at the start of …

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    Footnotes

    • Sources of funding: UK Medical Research Council; British Heart Foundation; EU Biomed Programme; CTSU.

    • For correspondence: PSC Secretariat, Radcliffe Infirmary, Oxford, UK. psc{at}ctsu.ox.ac.uk