eLetters

55 e-Letters

published between 2018 and 2021

  • Cochrane review should be revised due to overlooked trials, toxicity of adjuvant, mortality in mid-adult women and lack of discussion on observational studies with serious healthy-vaccinee effect

    Dear Dr. David Tovey,

    I have read your response [1,2] to the paper by Jøorgensen et al. published in BMJ Evidence-Based Medicine [3] relating to the recently published Cochrane Review on HPV vaccines [4], and would like to give my feedback on this issue.
    The key findings of your investigations are as follows:

    1. The Cochrane Review did not miss "nearly half of the eligible trials". A small number of studies were missed due to the primary focus on peer-reviewed reports in scientific journals, but addition of these data makes little or no difference to the results of the review for the main outcomes;
    2. The trials comparators were unambiguously, transparently, and accurately described;
    3. The selection of outcomes for benefits was appropriate and was consistent with World Health
    Organization guidance;
    4. The review included published and unpublished data on serious harms, and the findings on
    mortality were reported transparently and responsibly;
    5. The review was compliant with Cochrane’s current conflict of interest policy;
    6. Cochrane’s media coverage was cautious and balanced, but we recognize that there could be
    improvements in relation to transparency where external experts are quoted;
    7. The BMJ Evidence-Based Medicine article substantially overstated its criticisms.

    I would like to comment on your findings 1, 2, 4 and lastly, I added comments as 8. Most observational studies neg...

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  • More than 20,000 systematic reviews were published in 2017

    The number of systematic reviews being published each year is actually much larger than the already impressive number of 10,000 quoted. In 2017 over 20,000 were published; 20,661 are cited in the KSR Evidence database in early August 2018. KSR Evidence, includes all systematic reviews and meta-analyses published since 2015 and for many reviews provides a critical appraisal and a short, accessible bottom line. www.ksrevidence.com

  • Problems associated with not using a true placebo in clinical trials

    The problems associated with NOT using a true placebo in clinical trials - in this case GSK's trial for Cervarix - were discussed way back in 2009:

    FOOD AND DRUG ADMINISTRATION CENTER FOR BIOLOGICS EVALUATION AND RESEARCH

    VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEE

    September 9, 2009

    Pg166

    DR. DEBOLD: I just think in the absence of having a true placebo in the entire study, it is very, very difficult to sort out what the effects are here, what is it that we are really dealing with, what is the baseline, versus what potentially is caused by the so-called controls.

    In this particular study, not only was there two different strengths of Havrix used, there was alum used. In the pooled analysis there were a number of other vaccines used as the control, which makes it scientifically very difficult to sort things out.

  • Retraction notices in PubMed

    I searched PubMed for the retraction notices. The 3 retracted articles published by Elsevier have no retraction notices in PubMed. Retraction notices for the 2 articles in the Journal of the American Society of Hypertension were published in vol. 9, issue 10, this issue is indexed in PubMed and articles citations are in PubMed but the two retraction notices are missing. "Publishers of journals in PubMed must submit citation and abstract" (PubMed FAQ for publishers), these two notices should normally have been submitted by the publisher. As for the article published in the European Journal of Pharmaceutical Sciences, no retraction notice was found, information about the article being retracted is available in the original article but, as no retraction notice seems to be available, there is no information about the retracted status in PubMed. As PubMed is often the source used by researchers doing a study on retractions of articles (e.g. PMID: 28683764, PMID 26797347, PMID: 24928194) it is important to find this information in the database. Publishers should always publish retraction notices for retracted articles and submit the citations to PubMed when the journal is indexed in this database.

  • Response to Brodersen et al’s ’Overdiagnosis: what it is and what it isn’t'

    In their editorial, Brodersen et al. present two types of overdiagnosis. Their two types appear to be identical to two types of overdiagnosis we identified in research published in 2016 (Rogers WA and Mintzker Y. Getting clearer on overdiagnosis. J Eval Clin Prac 2016;22: 580-587). In that paper, we provide a detailed account of maldetection overdiagnosis and misclassification overdiagnosis, together with an analysis of the relevance of these two different types.
    This matter, including our request for a correction, is fully explained in our letter published in this journal: Response to Brodersen et al’s ’Overdiagnosis: what it is and what it isn’t' (http://ebm.bmj.com/content/early/2018/03/29/bmjebm-2018-110948).

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