TY - JOUR T1 - Review: hormone therapy may reduce the risk of death in younger but not older postmenopausal women JF - Evidence Based Medicine JO - Evid Based Med SP - 10 LP - 10 DO - 10.1136/ebm.10.1.10 VL - 10 IS - 1 A2 - , Y1 - 2005/02/01 UR - http://ebm.bmj.com/content/10/1/10.abstract N2 - Salpeter SR, Walsh JM, Greyber E, et al. Mortality associated with hormone replacement therapy in younger and older women: a meta-analysis. J Gen Intern Med 2004;19:791–804.OpenUrlCrossRefPubMedWeb of Science 
 
 Q Does hormone therapy (HT) affect the risk of death differently in younger and older postmenopausal women? Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★☆☆ Data sources: Medline, EMBASE/Excerpta Medica, CINAHL, and Cochrane library (1966 to September 2002); journal hand searches through April 2003; and bibliographies. Study selection and assessment: randomised controlled trials (RCTs) that compared HT with a control intervention (placebo, no treatment, or calcium supplementation), were >6 months in duration, and reported ⩾1 death. Study quality was assessed for method of randomisation, allocation concealment, blinding, description of withdrawals and dropouts, and intention to treat analysis. Studies received a quality criteria score of A (all criteria met), B (⩾1 criteria met), or C (0 criteria met). Outcomes: total death, cardiovascular (CV) death, cancer death, and death from other causes. Trials were divided into those with mean age at baseline <60 or >60 years. 30 RCTs (n = 26 708, age range 36–87 y) met the inclusion criteria. The quality scores … ER -