TY - JOUR T1 - Clopidogrel was effective in patients who have MI with ST segment elevation receiving aspirin and fibrinolytic therapy JF - Evidence Based Medicine JO - Evid Based Med SP - 111 LP - 111 DO - 10.1136/ebm.10.4.111 VL - 10 IS - 4 A2 - , Y1 - 2005/08/01 UR - http://ebm.bmj.com/content/10/4/111.abstract N2 - Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 2005;352:1179–89.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In patients who have myocardial infarction (MI) with ST segment elevation and are receiving aspirin and standard fibrinolytic therapy, is the addition of clopidogrel beneficial? Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★★★ Design: randomised controlled trial (Clopidogrel as Adjunctive Reperfusion Therapy [CLARITY]–Thrombolysis in Myocardial Infarction [TIMI] 28 Study). Allocation: concealed.* Blinding: blinded (patients and healthcare providers).* Follow up period: to the start of coronary angiography (median 3.5 d), or in patients not having angiography, to hospital discharge or day 8, whichever came first. Setting: 319 sites in 23 countries. Patients: 3491 patients who were 18–75 years (mean age 57 y, 80% men); presented within 12 hours after the onset of ischaemic discomfort at rest lasting >20 minutes; had ST segment elevation of ⩾0.1 mV in ⩾2 contiguous limb leads, ST segment elevation of ⩾0.2 mV in ⩾2 contiguous precordial … ER -