TY - JOUR T1 - Daily vitamin C prevented development of complex regional pain syndrome in adults with wrist fractures JF - Evidence Based Medicine JO - Evid Based Med SP - 48 LP - 48 DO - 10.1136/ebm.13.2.48 VL - 13 IS - 2 A2 - , Y1 - 2008/04/01 UR - http://ebm.bmj.com/content/13/2/48.abstract N2 - P E ZollingerDr P E Zollinger, Ziekenhuis Rivierenland, The Netherlands; pe.zollinger@tiscali.nlDesign:randomised controlled trial.Allocation:{concealed}*.†Blinding:blinded (patients and physicians).†Setting:emergency departments in 3 hospitals in the Netherlands.Patients:416 patients, ⩾18 years of age, with 427 wrist fractures (82% in women).Intervention:1 of 3 daily doses of vitamin C (200 mg [n = 96 fractures], 500 mg [n = 114], or 1500 mg [n = 118]) or placebo (n = 99), started on the day of the fracture and taken in 2 capsules/day for 50 days.Outcomes:complex regional pain syndrome (CRPS) type 1 within 1 year after fracture, diagnosed if 4 of the 5 following symptoms were present at or distal to the wrist and occurred or increased after … ER -