TY - JOUR T1 - Vaccinating infants with a wide long needle was non-inferior to a narrow short needle for immune response JF - Evidence Based Medicine JO - Evid Based Med SP - 41 LP - 41 DO - 10.1136/ebm.12.2.41 VL - 12 IS - 2 A2 - , Y1 - 2007/04/01 UR - http://ebm.bmj.com/content/12/2/41.abstract N2 - Diggle L, Deeks JJ, Pollard AJ. Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial. BMJ 2006;333:571. 
 
 Q Is vaccination of infants with a wide long needle non-inferior to a narrow short needle for immune response and local reactions? Clinical impact ratings Paediatrics ★★★★★★★ Infectious disease ★★★★★★☆ Public health ★★★★★★☆ Design: randomised controlled non-inferiority trial. Allocation: concealed.* Blinding: blinded (data entry clerks and laboratory staff).* Follow up period: 3–4.5 months. Setting: 18 general practices in 2 primary care trusts in the UK. Participants: 696 healthy infants due to receive their first immunisation (mean age 62 d, mean weight 5300 g, 52% boys). Exclusion criteria were <37 weeks gestation, birth weight <2500 g, or treatments or conditions that could bias evaluation of immune response. Intervention: infants were allocated to vaccination with a 23 gauge, 25 mm needle (wide long needle, n = 240); a 25 gauge, 16 mm needle (narrow short needle, n = 230); or a 25 gauge, 25 mm needle (narrow long needle, n = 226). At 2, 3, and 4 months of age, infants received … ER -