TY - JOUR T1 - Melanoma of the scalp and neck had greater risk of melanoma-specific mortality than melanoma of the extremities JF - Evidence Based Medicine JO - Evid Based Med SP - 155 LP - 155 DO - 10.1136/ebm.13.5.155 VL - 13 IS - 5 A2 - , Y1 - 2008/10/01 UR - http://ebm.bmj.com/content/13/5/155.abstract N2 - N E ThomasDr N E Thomas, University of North Carolina, Chapel Hill, NC, USA; nancy_thomas@med.unc.eduIn patients with melanoma, are tumours of the scalp or neck associated with increased risk of melanoma-specific mortality?Design:inception cohort.Setting:13 Surveillance, Epidemiology, and End Results (SEER) registries in the USA.Patients:51 704 white, non-Hispanic adults ⩾20 years of age (mean age 56 y, 56% men) who had a first invasive microscopically confirmed cutaneous melanoma and were included in the National Cancer Institute SEER-13 registries between 1992 and 2003 (>42% followed up for ⩾5 years).Prognostic factors:tumour site (scalp/neck, extremities, trunk, face/ears, and unknown), other tumour characteristics (Breslow thickness, ulceration, lymph node involvement, and histological subtype), and patient characteristics (age at diagnosis and sex).Outcome:melanoma-specific mortality.9% of patients died from melanoma during follow-up. Melanoma-specific survival was lower for patients with scalp/neck melanoma than for those with melanoma in other locations (5 … ER -