TY - JOUR T1 - Review: anticonvulsants are better than placebo for reducing the frequency of migraine attacks JF - Evidence Based Medicine JO - Evid Based Med SP - 16 LP - 16 DO - 10.1136/ebm.10.1.16 VL - 10 IS - 1 A2 - , Y1 - 2005/02/01 UR - http://ebm.bmj.com/content/10/1/16.abstract N2 - Chronicle E, Mulleners W. Anticonvulsant drugs for migraine prophylaxis. Cochrane Database Syst Rev 2004;(3):CD003226. 
 
 Q In patients with migraine, are anticonvulsants more effective than placebo for preventing or reducing the intensity of migraine attacks? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆IM/Ambulatory care ★★★★★★☆ Neurology ★★★★★☆☆ Data sources: Medline (up to April 2003); the Cochrane Central Register of Controlled Trials (up to April 2003); review article references; books on headache; contact with drug companies, authors, and experts; and hand searches of Headache and Cephalalgia. Study selection and assessment: randomised controlled trials (RCTs) that compared anticonvulsants given regularly during headache free intervals in adults >18 years of age with placebo, no intervention, other drug treatments, or behavioural or physical therapies. Methodological quality was assessed using the Jadad 5 point scale. Outcomes: headache frequency (number of migraine attacks measured at 28 d), headache index measures (frequency and intensity or duration), and adverse events. 15 RCTs met the selection criteria. Anticonvulsants investigated … ER -