TY - JOUR T1 - Review: the renoprotective effects of ACE inhibitors and ARBs independent of blood pressure control are uncertain JF - Evidence Based Medicine JO - Evid Based Med SP - 145 LP - 145 DO - 10.1136/ebm.11.5.145 VL - 11 IS - 5 A2 - , Y1 - 2006/10/01 UR - http://ebm.bmj.com/content/11/5/145.abstract N2 - Casas JP, Chua W, Loukogeorgakis S, et al. Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet 2005;366:2026–33.OpenUrlCrossRefPubMedWeb of Science 
 
 Q Do angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) have renoprotective effects independent of blood pressure (BP) control? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Nephrology ★★★★★★☆ Endocrine ★★★★★☆☆ Data sources: Medline, EMBASE/Excerpta Medica, and the Cochrane Library (1960 to January 2005); and references of relevant studies and reviews. Study selection and assessment: randomised controlled trials (RCTs) with ⩾1 year follow up that examined the effect of drug treatment with a BP lowering action on progression of renal disease. 127 RCTs (150 comparisons) with mean follow up of 4.2 years met the selection criteria. Outcomes: end stage renal disease (ESRD) (need for kidney transplantation or dialysis) and doubling of serum creatinine. Changes in BP were similar across the 5 outcomes; all but 1 showed no difference in the degree of change in systolic and diastolic BP between … ER -