TY - JOUR T1 - Review: alarm features in dyspepsia do not have high diagnostic accuracy for predicting upper gastrointestinal cancer JF - Evidence Based Medicine JO - Evid Based Med SP - 55 LP - 55 DO - 10.1136/ebm.12.2.55 VL - 12 IS - 2 A2 - , Y1 - 2007/04/01 UR - http://ebm.bmj.com/content/12/2/55.abstract N2 - Vakil N, Moayyedi P, Fennerty MB, et al. Limited value of alarm features in the diagnosis of upper gastrointestinal malignancy: systematic review and meta-analysis. Gastroenterology 2006;131:390–401.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In patients with dyspepsia, what is the accuracy of alarm features (eg, dysphagia, weight loss, or anaemia) for detecting upper gastrointestinal (GI) cancer? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Gastroenterology ★★★★★★☆ Data sources: Medline (1966–2003), CINAHL (1982 to Jan 2005), EMBASE/Excerpta Medica (1988 to Jan 2005), and Cochrane Controlled Trials Register (Jan 2005). Study selection and assessment: prospective studies that evaluated dyspepsia and alarm symptoms in unselected adults (>16 y of age), included >100 patients, compared symptoms with endoscopic diagnosis, and diagnosed >1 upper GI cancer. Studies were pooled using a random effects model. Study quality was assessed. 18 studies met the selection criteria. Outcomes: sensitivity, specificity, and likelihood ratios. Pooled estimates showed that clinical … ER -