TY - JOUR T1 - Black cohosh and St John’s wort reduced climacteric and depressive symptoms JF - Evidence Based Medicine JO - Evid Based Med SP - 148 LP - 148 DO - 10.1136/ebm.11.5.148 VL - 11 IS - 5 A2 - , Y1 - 2006/10/01 UR - http://ebm.bmj.com/content/11/5/148.abstract N2 - Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John’s wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247–55.OpenUrlPubMed 
 
 Q In women with climacteric complaints, does a fixed combination of black cohosh (Cimicifuga racemosa) and St John’s wort (Hypericum perforatum) extracts reduce symptoms? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Gynaecology ★★★★★★☆ Design: randomised controlled trial (RCT). Allocation: concealed.* Blinding: blinded (patients, healthcare providers, {data collectors, outcome assessors, data analysts, and data safety committee}†).* Follow up period: 16 weeks. Setting: a clinic in Berlin, Germany. Patients: 301 women who were 45–60 years of age (mean age 52 y) and had climacteric symptoms for ⩾3 months, a Menopause Rating Scale score ⩾0.4 on ⩾3 items, a Hamilton Depression Rating Scale Total score of 15–23 points, and a score ⩾2 on the Hamilton Depression Rating Scale item 1. Exclusion criteria included any treatment to alleviate climacteric symptoms in the previous 12 … ER -