TY - JOUR T1 - Routine rotavirus vaccinations of infants cost US$138 per case averted and US$197 190 per life year saved from a societal perspective JF - Evidence Based Medicine JO - Evid Based Med SP - 153 LP - 153 DO - 10.1136/ebm.12.5.153 VL - 12 IS - 5 A2 - , Y1 - 2007/10/01 UR - http://ebm.bmj.com/content/12/5/153.abstract N2 - Widdowson MA, Meltzer MI, Zhang X, et al. Cost-effectiveness and potential impact of rotavirus vaccination in the United States. Pediatrics 2007;119:684–97.OpenUrlAbstract/FREE Full Text 
 
 Q Are routine rotavirus vaccinations (3 times/infant) cost effective in the US? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Paediatrics (general) ★★★★★★☆ Public health ★★★★★★☆ Design: cost effectiveness study using a probabilistic (Monte Carlo) model. Setting: nationwide in the US. Patients: a hypothetical cohort of 4 010 000 children monitored from 0 to 59 months of age. Intervention: routine vaccinations for infants at 2, 4, and 6 months of age with a pentavalent human bovine reassortant rotavirus vaccine (PVR) (RotaTeq; Merck, Whitehouse Station, NJ, USA) or no vaccinations. Outcomes: deaths, hospital admissions, emergency department visits, office visits, and episodes with home care; and the cost effectiveness ratio per case (any disease) averted, per serious case (hospital admission, … ER -