TY - JOUR T1 - Loop diuretics and angiotensin converting enzyme inhibitors increased risk of hospital admission for lithium toxicity JF - Evidence Based Medicine JO - Evid Based Med SP - 28 LP - 28 DO - 10.1136/ebm.10.1.28 VL - 10 IS - 1 A2 - , Y1 - 2005/02/01 UR - http://ebm.bmj.com/content/10/1/28.abstract N2 - Juurlink DN, Mamdani MM, Kopp A, et al. Drug-induced lithium toxicity in the elderly: a population-based study. J Am Geriatr Soc 2004;52:794–8.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In older persons, is use of diuretics, angiotensin converting enzyme (ACE) inhibitors, or non-steroidal anti-inflammatory drugs (NSAIDs) associated with hospital admission for lithium toxicity? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Emergency Medicine ★★★★★☆☆ Neurology ★★★★★☆☆ Geriatrics ★★★★★☆☆ Design: population based, nested, case control study with analysis of multiple linked healthcare databases over 10 years. Setting: Ontario, Canada. Patients: 10 615 patients ⩾66 years of age (mean age 72 y, 62% women) who were receiving uninterrupted lithium treatment and resided in Ontario, Canada. Assessment of risk factors: use of diuretic (alone or in combination with another agent), ACE inhibitor, or prescription NSAID (including cyclooxygenase 2 inhibitors). Thiazide type and loop diuretics were examined separately. Outcome: hospital admission with diagnosis of lithium toxicity within 28 days … ER -