TY - JOUR T1 - Low dose aspirin lowered stroke risk but not risks of MI or cardiovascular deaths in women JF - Evidence Based Medicine JO - Evid Based Med SP - 137 LP - 137 DO - 10.1136/ebm.10.5.137 VL - 10 IS - 5 A2 - , Y1 - 2005/10/01 UR - http://ebm.bmj.com/content/10/5/137.abstract N2 - Ridker PM, Cook NR, Lee IM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005;352:1293–304.OpenUrlCrossRefPubMedWeb of Science 
 
 Q Is low dose aspirin effective for the primary prevention of cardiovascular disease in women? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Neurology ★★★★★★☆ Haematology ★★★★★★☆ Design: randomised, placebo controlled trial (Women’s Health Study). Allocation: {concealed*}†. Blinding: blinded {healthcare providers, participants, data collectors, and outcome assessors}†.* Follow up period: mean 10 years. Setting: USA and Puerto Rico. Participants: 39 876 women ⩾45 years of age (mean age 55 y) who had no history of coronary artery disease, cerebrovascular disease, cancer (except non-melanoma skin cancer), or other major chronic illness; contraindication to the study medications; were not taking aspirin, non-steroidal anti-inflammatory drugs, anticoagulants, or corticosteroids; and were not taking vitamin A or E, or ß carotene supplements more than once per week. Intervention: aspirin, 100 mg every other day (n = 19 934) or placebo (n = 19 942). Outcomes: first major cardiovascular event (non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death); individual cardiovascular endpoints; and adverse events. Patient follow up: 97% (intention to treat analysis). The table shows … ER -