TY - JOUR T1 - Testosterone supplementation did not prevent cognitive decline or increase bone mineral density in older men JF - Evidence Based Medicine JO - Evid Based Med SP - 71 LP - 71 DO - 10.1136/ebm.13.3.71 VL - 13 IS - 3 A2 - , Y1 - 2008/06/01 UR - http://ebm.bmj.com/content/13/3/71.abstract N2 - Dr M H Emmelot-VonkCorrespondence to: Dr M H Emmelot-Vonk, University Medical Center, Utrecht, The Netherlands; m.h.emmelotvonk@umcutrecht.nlDesign:randomised, placebo controlled trial.Allocation:{concealed}*.†Blinding:blinded (participants and clinicians).†Setting:University Medical Centre in Utrecht, the Netherlands.Patients:237 men 60–80 years of age (mean age 67 y) who had testosterone concentrations <13.7 nmol/l (394.8 ng/dl). Exclusion criteria included myocardial infarction or cerebrovascular accident in the past 6 months; heart failure unless medically treated and not symptomatic; cancer in the past 5 years except non-melanoma skin cancer and hormone dependent tumor; renal or liver disease; haematological abnormalities; epilepsy or use of antiepileptic medication; >1 migraine per month; diabetes mellitus; fasting glucose concentration ⩾6.9 mmol/l (124 mg/dl); corticosteroid use (⩾7.5 mg/d in the past 6 mo except for prednisolone use … ER -