TY - JOUR T1 - Review: magnetic resonance imaging alone is of limited usefulness in diagnosing multiple sclerosis JF - Evidence Based Medicine JO - Evid Based Med SP - 155 LP - 155 DO - 10.1136/ebm.11.5.155 VL - 11 IS - 5 A2 - , Y1 - 2006/10/01 UR - http://ebm.bmj.com/content/11/5/155.abstract N2 - Whiting P, Harbord R, Main C, et al. Accuracy of magnetic resonance imaging for the diagnosis of multiple sclerosis: systematic review. BMJ 2006;332:875–84.OpenUrlAbstract/FREE Full Text 
 
 Q How accurate is magnetic resonance imaging (MRI) for diagnosing multiple sclerosis (MS)? Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Neurology ★★★★★☆☆ Data sources: 12 electronic databases (to September or November 2004), reference lists, and the National Institute for Health and Clinical Excellence MS guidelines. Study selection and assessment: published and unpublished studies in any language that evaluated the accuracy of MRI for early diagnosis of MS in patients presenting with suspected disease. 18 prospective cohort studies (n = 2102) and 11 studies of other designs (mainly case control, n = 2527) met the selection criteria. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS) criteria were used to assess quality of individual studies. Outcomes: sensitivity, specificity, positive and negative likelihood ratios (LRs), and diagnostic odds ratio (OR) (the odds of positivity in people with MS, divided by the odds of positivity in … ER -