TY - JOUR T1 - Review: SSRIs lead to improvement in depression by the end of the first week JF - Evidence Based Medicine JO - Evid Based Med SP - 72 LP - 72 DO - 10.1136/ebm.12.3.72 VL - 12 IS - 3 A2 - , Y1 - 2007/06/01 UR - http://ebm.bmj.com/content/12/3/72.abstract N2 - Taylor MJ, Freemantle N, Geddes JR, et al. Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry 2006;63:1217–23.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In patients with depression, do selective serotonin reuptake inhibitors (SSRIs) have an early or delayed onset of antidepressant action? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ GP/FP/Mental health ★★★★★★☆ Psychiatry ★★★★★☆☆ Data sources: CENTRAL (Cochrane Central Register of Controlled Trials) and reference lists of randomised controlled trials (RCTs) and systematic reviews. Study selection and assessment: RCTs in any language were included if they reported outcome measures for SSRI treatment at ⩾2 time points. RCTs in older adults (⩾65 y) or in patients with specific comorbidities were excluded. 50 RCTs were identified, of which 28 (n = 5872) provided sufficient data for analysis. SSRIs used were … ER -