TY - JOUR T1 - Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis JF - Evidence Based Medicine JO - Evid Based Med SP - 74 LP - 74 DO - 10.1136/ebm.200X.000na VL - 12 IS - 3 A2 - , Y1 - 2007/06/01 UR - http://ebm.bmj.com/content/12/3/74.abstract N2 - Rintelen B, Neumann K, Leeb BF. A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis. Arch Intern Med 2006;166:1899–906.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In patients with knee or hip osteoarthritis, is diacerein more effective than placebo or other active treatments in reducing pain and improving function? Clinical impact ratings Rheumatology ★★★★★★☆ Data sources: PubMed, Medline, EMBASE/Excerpta Medica, Google, Yahoo, AltaVista, arthritis journals, personal files, reference lists, and the drug company. Study selection and assessment: randomised controlled trials (RCTs), published or reported in English, French, or German between 1985 and 2004, that compared diacerein with placebo or another active treatment in patients with knee or hip osteoarthritis. 19 RCTs (n = 3058, mean age range 48–67 y, 68% women) met the selection criteria, 16 of which were double blinded. Methodological quality of individual trials was assessed using the Jadad scale. Outcomes: pain, function, and use of other medications for pain relief. Outcomes were assessed at 2 time points: at the end of active treatment (duration 1–36 mo, median 3 … ER -