TY - JOUR T1 - 5 days of nitrofurantoin was equivalent to 3 days of trimethoprim-sulfamethoxazole for women with non-complicated cystitis JF - Evidence Based Medicine JO - Evid Based Med SP - 80 LP - 80 DO - 10.1136/ebm.13.3.80 VL - 13 IS - 3 A2 - , Y1 - 2008/06/01 UR - http://ebm.bmj.com/content/13/3/80.abstract N2 - Dr K GuptaCorrespondence to: Dr K Gupta, Yale University, West Haven, CT, USA; kalpana.gupta@yale.eduDesign:randomised controlled equivalence trial.Allocation:unclear concealment.*Blinding:unblinded.*Setting:a university-based outpatient clinic in the USA.Patients:338 women 18–45 years of age (median age 21 y) who were in good general health and had symptoms of acute cystitis (dysuria, frequency, and/or urgency) and a urine culture with ⩾102 colony forming units/ml of a uropathogen. Exclusion criteria included pregnancy, lactation, lack of regular contraceptive use, diabetes mellitus, known anatomical abnormalities of the urinary tract, allergy to study drugs, use of an antimicrobial agent for <2 weeks, and use of prophylactic antibiotics.Intervention:nitrofurantoin, 100 mg twice daily for 5 days (n = 171), or trimethoprim-sulfamethoxazole (TMP-SMX), 1 double-strength tablet twice daily for 3 days (n = 167).Outcomes:clinical cure at 30 days (percentage … ER -