TY - JOUR T1 - Isosorbide dinitrate plus hydralazine was effective for advanced heart failure in black patients JF - Evidence Based Medicine JO - Evid Based Med SP - 44 LP - 44 DO - 10.1136/ebm.10.2.44 VL - 10 IS - 2 A2 - , Y1 - 2005/04/01 UR - http://ebm.bmj.com/content/10/2/44.abstract N2 - Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 2004;351:2049–57.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In black patients with New York Heart Association (NYHA) class III or IV heart failure (HF) with dilated ventricles, is a fixed dose of isosorbide dinitrate plus hydralazine (ID+H) better than placebo? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Cardiology ★★★★★★☆ Design: randomised placebo controlled trial (African-American Heart Failure Trial [A-HeFT]). Allocation: concealed.* Blinding: blinded (clinicians, patients, data collectors, outcome assessors, monitoring committee, and statisticians).* Follow up period: 18 months. Setting: 161 centres in the US. Patients: 1050 adults (mean age 57 y, 60% men) self identified as black who had NYHA class III or IV HF for ⩾3 months, had left ventricular dysfunction in the preceding 6 months, and were receiving standard HF therapy. Exclusion criteria included acute MI, stroke, cardiac surgery, or … ER -