TY - JOUR T1 - Review: antidepressants increase clinical response and remission in bipolar depression without increasing induction of mania JF - Evidence Based Medicine JO - Evid Based Med SP - 45 LP - 45 DO - 10.1136/ebm.10.2.45 VL - 10 IS - 2 A2 - , Y1 - 2005/04/01 UR - http://ebm.bmj.com/content/10/2/45.abstract N2 - Gijsman HJ, Geddes JR, Rendell JM, et al. Antidepressants for bipolar depression: a systematic review of randomized, controlled trials. Am J Psychiatry 2004;161:1537–47.OpenUrlCrossRefPubMedWeb of Science 
 
 Q What is the efficacy and safety of antidepressants for short term treatment of bipolar depression? Clinical impact ratings Psychiatry ★★★★★★☆ GP/FP/Mental health ★★★★★★★ Data sources: Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials register (December 2002), Cochrane Library, reference lists of identified studies, other relevant papers, and major textbooks. Study selection and assessment: randomised, controlled, double blind trials published in any language that compared antidepressants with placebo or alternative drugs (ie, mood stabilisers, anticonvulsants, or other antidepressants) in patients with a current depressive or mixed depressive/manic episode with or without psychotic symptoms who had had ⩾1 previous episode of mania or hypomania. Quality of studies was assessed. Outcomes: clinical response and remission rates (observer rated symptom … ER -