TY - JOUR T1 - Fluoxetine plus cognitive behavioural therapy was most effective for adolescents with major depressive disorder JF - Evidence Based Medicine JO - Evid Based Med SP - 46 LP - 46 DO - 10.1136/ebm.10.2.46 VL - 10 IS - 2 A2 - , Y1 - 2005/04/01 UR - http://ebm.bmj.com/content/10/2/46.abstract N2 - March J, Silva S, Petrycki S, et al. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. JAMA 2004;292:807–20.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In adolescents with major depressive disorder (MDD), how do fluoxetine, cognitive behavioural therapy (CBT), and their combination compare for effectiveness? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Mental health ★★★★★★☆ Psychiatry ★★★★★★☆ Paediatrics ★★★★★★☆ Design: 2 x 2 factorial randomised placebo controlled trial. Allocation: {concealed*}†. Blinding: blinded (patients and healthcare providers [fluoxetine v placebo comparison] and outcome assessors).* Follow up period: 12 weeks. Setting: outpatient clinic in the US. Patients: 439 adolescents (mean age 14.6 y, 54% girls) who had a DSM-IV diagnosis of major depressive disorder, could attend an outpatient clinic, scored ⩾45 on the Children’s Depression Rating Scale–Revised (CDRS–R), had a full scale IQ ⩾80, and were not taking antidepressants. Exclusion criteria included bipolar disorder, severe conduct disorder, substance abuse/dependence, 2 failed selective serotonin reuptake inhibitor trials (SSRI), and poor response to CBT. Intervention: (1) fluoxetine, from 10 mg/day to a maximum of 40 mg/day … ER -