TY - JOUR T1 - Prompt insertion of tympanostomy tubes in infants and toddlers with persistent middle ear effusion did not improve developmental outcomes at 9–11 years of age JF - Evidence Based Medicine JO - Evid Based Med SP - 80 LP - 80 DO - 10.1136/ebm.12.3.80 VL - 12 IS - 3 A2 - , Y1 - 2007/06/01 UR - http://ebm.bmj.com/content/12/3/80.abstract N2 - Paradise JL, Feldman HM, Campbell TF, et al. Tympanostomy tubes and developmental outcomes at 9 to 11 years of age. N Engl J Med 2007;356:248–61.OpenUrlCrossRefPubMed 
 
 Q In infants and toddlers with persistent middle ear effusion, is prompt insertion of tympanostomy tubes (ITTs) more effective than delayed ITTs for developmental outcomes at 9–11 years of age? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Paediatrics ★★★★★★☆ Surgery—ear nose throat ★★★★★★☆ Design: randomised controlled trial. Allocation: {concealed*}†. Blinding: blinded (outcome assessors, data analysts, and {data collectors}†).* Follow up period: up to 11 years. Setting: 2 hospitals and 6 paediatric group practices in or near Pittsburgh, USA. Patients: 429 children (about 58% boys) who were 2 months to 3 years of age and met 1 of the following criteria: persistent bilateral middle ear effusion for 90 days, persistent unilateral effusion for 135 days, or intermittent effusion for specified proportions of longer periods (eg, … ER -