TY - JOUR T1 - Daily folic acid supplementation for 3 years improved cognitive function in older persons JF - Evidence Based Medicine JO - Evid Based Med SP - 83 LP - 83 DO - 10.1136/ebm.12.3.83 VL - 12 IS - 3 A2 - , Y1 - 2007/06/01 UR - http://ebm.bmj.com/content/12/3/83.abstract N2 - Durga J, van Boxtel MP, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208–16.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In older persons, does daily folic acid supplementation for 3 years improve cognitive function? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Geriatrics ★★★★★★☆ GP/FP/Mental Health ★★★★★☆☆ Genetics ★★★★★☆☆ Neurology ★★★★★☆☆ Psychiatry ★★★★★☆☆ Design: randomised placebo controlled trial (Folic Acid and Carotid Intima media Thickness [FACIT] trial). Allocation: concealed.* Blinding: blinded {clinicians, participants, data collectors, outcome assessors, data safety and monitoring committee, manuscript writers, and data analysts/statisticians}†.* Follow up period: 3 years. Setting: Gelderland province, the Netherlands. Participants: 818 men and postmenopausal women 50–70 years of age (mean age 60 y, 72% men) recruited from municipal and blood bank registries who reported ⩾80% compliance during a 6 week placebo run in period. 51 participants had 1 household member who was also enrolled and received … ER -