TY - JOUR T1 - Review: anti–cyclic citrullinated peptide antibody is a more specific test for rheumatoid arthritis than rheumatoid factor JF - Evidence Based Medicine JO - Evid Based Med SP - 183 LP - 183 DO - 10.1136/ebm.12.6.183 VL - 12 IS - 6 A2 - , Y1 - 2007/12/01 UR - http://ebm.bmj.com/content/12/6/183.abstract N2 - Are rheumatoid factor (RF) and anti–cyclic citrullinated peptide antibody (anti-CCP) accurate tests for rheumatoid arthritis (RA)?Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med 2007;146:797–808.Clinical impact ratings Rheumatology ★★★★★★★ Internal medicine ★★★★★★⋆ Data sources: Medline (to September 2006) and reference lists.Study selection and assessment: studies published after 1987 that evaluated the accuracy of RF or anti-CCP for diagnosis of RA in ⩾10 participants. 50 studies of RF (n = 15 286, median age 53 y, 68% women) and 37 studies of anti-CCP (n = 14 949, median age 57 y, 59% women) met the selection criteria.Outcomes: pooled sensitivity, specificity, and positive and negative likelihood ratios (LRs). The reference standard for RA was the 1987 revised American College of Rheumatology criteria. Anti-CCP and IgM RF had similar … ER -