TY - JOUR T1 - Haemoglobin A<sub>1c</sub> concentrations were associated with increased cardiovascular disease and all cause mortality JF - Evidence Based Medicine JO - Evid Based Med SP - 57 LP - 57 DO - 10.1136/ebm.10.2.57 VL - 10 IS - 2 A2 - , Y1 - 2005/04/01 UR - http://ebm.bmj.com/content/10/2/57.abstract N2 - Khaw KT, Wareham N, Bingham S, et al. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European Prospective Investigation into Cancer in Norfolk. Ann Intern Med 2004;141:413–20.OpenUrlCrossRefPubMedWeb of Science 
 
 Q What is the relation between haemoglobin (Hb) A1c concentrations and coronary heart disease (CHD) events, cardiovascular disease (CVD) events, and all cause mortality? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Cardiology ★★★★★★☆ Endocrine ★★★★★☆☆ Design: cohort study (European Prospective Investigation into Cancer in Norfolk [EPIC-Norfolk]) with a mean follow up of 6 years. Setting: Norfolk, UK. Patients: 10 232 patients 45–79 years of age (54% women, 2.4% with diabetes) who were recruited from general practice registers and had baseline data on a health and lifestyle questionnaire and HbA1c concentrations. Risk factors: HbA1c concentrations, known diabetes, age, body mass index, waist-to-hip ratio, systolic blood pressure, cholesterol concentrations, triglyceride concentrations, cigarette smoking, and history of heart attack or stroke. Outcomes: CHD events (hospital admission or death from CHD), CVD events (hospital admission … ER -