TY - JOUR T1 - Radical prostatectomy reduced death and progression more than watchful waiting in early prostate cancer JF - Evidence Based Medicine JO - Evid Based Med SP - 168 LP - 168 DO - 10.1136/ebm.10.6.168 VL - 10 IS - 6 A2 - , Y1 - 2005/12/01 UR - http://ebm.bmj.com/content/10/6/168.abstract N2 - Bill-Axelson A, Holmberg L, Ruutu M, et al. Radical prostatectomy versus watchful waiting in early prostate cancer. N Engl J Med 2005;352:1977–84.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In men with early prostate cancer, how do radical prostatectomy (RP) and watchful waiting (WW) compare? Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Surgery—urology ★★★★★★☆ Oncology ★★★★★★☆ Nephrology ★★★★★★☆ Design: randomised controlled trial (Scandinavian Prostate Cancer Group Study Number 4). Allocation: {concealed}†.* Blinding: blinded {outcome assessors, data safety and monitoring committee, and data analysts}†.* Follow-up period: mean 8.5–8.8 years (median 8.2 y). Setting: 14 centres in Sweden, Finland, and Iceland. Patients: 695 men <75 years of age (mean age 65 y) with newly diagnosed, untreated, localised prostate cancer; tumour stage T0d (later changed to T1b), T1, or T2; life expectancy >10 years; prostate specific antigen (PSA) level <50 ng/ml; and no abnormalities on bone scan. Intervention: RP (n = 347) or WW (n = 348). Outcomes: death from prostate cancer, distant metastasis, local progression, and death from any cause. Patient follow up: 100% (intention to treat analysis). Fewer patients … ER -