TY - JOUR T1 - Review: statins reduce stroke but not stroke mortality JF - Evidence Based Medicine JO - Evid Based Med SP - 73 LP - 73 DO - 10.1136/ebm.10.3.73 VL - 10 IS - 3 A2 - , Y1 - 2005/06/01 UR - http://ebm.bmj.com/content/10/3/73.abstract N2 - Amarenco P, Labreuche J, Lavallee P, et al. Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis. Stroke 2004;35:2902–9.OpenUrlAbstract/FREE Full Text 
 
 Q Do 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduce fatal and non-fatal stroke more than placebo or usual care? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal Medicine ★★★★★☆☆ Endocrine ★★★★★★☆ Neurology ★★★★★★☆ Data sources: Medline and reference lists of identified trials. Study selection and assessment: randomised controlled trials (RCTs) and previous meta-analyses published before August 2003 that compared statins with placebo or usual care, included stroke events (brain infarction and haemorrhage) as outcomes, and used intention to treat analysis. Outcomes: all stroke, fatal stroke, haemorrhagic stroke, the relation between stroke and low density lipoprotein cholesterol (LDL-C) reduction, and the relation between LDL-C reduction and change in carotid artery intima media thickness (IMT). 26 RCTs (n = 94 128) … ER -