TY - JOUR T1 - Review: fixed-dose drug combinations improve medication compliance compared with free-drug regimens JF - Evidence Based Medicine JO - Evid Based Med SP - 18 LP - 18 DO - 10.1136/ebm.13.1.18 VL - 13 IS - 1 A2 - , Y1 - 2008/02/01 UR - http://ebm.bmj.com/content/13/1/18.abstract N2 - F H MesserliDr F H Messerli, Columbia University College of Physicians and Surgeons, New York, NY, USA; fmesserl@chpnet.orgAim:in patients with chronic conditions, do fixed-dose drug combinations improve medication compliance compared with the same drugs taken separately?Search methods:Medline (to November 2005), reference lists, and drug companies.Study selection and assessment:English-language studies that compared fixed-dose drug combinations with free-drug regimens of the same medications and reported medication compliance. 9 studies (n = 20 242, mean age 40–68 y, 50–89% men) met the selection criteria. The chronic condition was hypertension in 4 studies, diabetes in 2 studies, tuberculosis in 2 studies, and human immunodeficiency virus infection in 1 study. Duration … ER -