TY - JOUR T1 - Diuretics were superior to calcium channel blockers and short term ACE inhibitors for reducing heart failure in hypertension JF - Evidence Based Medicine JO - Evid Based Med SP - 17 LP - 17 DO - 10.1136/ebm.12.1.17 VL - 12 IS - 1 A2 - , Y1 - 2007/02/01 UR - http://ebm.bmj.com/content/12/1/17.abstract N2 - Davis BR, Piller LB, Cutler JA, et al. Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Circulation 2006;113:2201–10. 
 
 Q In high risk patients with hypertension, what is the effect of chlorthalidone, amlodipine, and lisinopril on hospitalised or fatal heart failure (HF)? Does the effect differ across time and prespecified subgroups? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★★ Cardiology ★★★★★★☆ Design: randomised controlled trial (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [ALLHAT]). Allocation: {concealed*}†. Blinding: blinded {patients, clinicians, data collectors, outcome assessors, and investigators}‡.* Follow-up period: mean 4.9 years. Setting {623 centers in the US, Canada, Puerto Rico, and the US Virgin Islands.}† Patients 33 357 patients who were ⩾55 years of age (mean age 67 y, 53% men) and had stage 1 or 2 hypertension plus an additional risk factor for coronary artery disease. Exclusion criteria were history of hospitalised or symptomatic HF or known left ventricular … ER -