TY - JOUR T1 - Daily oral vitamin B-12 with or without folic acid for 24 weeks did not improve cognitive function in elderly people JF - Evidence Based Medicine JO - Evid Based Med SP - 18 LP - 18 DO - 10.1136/ebm.12.1.18 VL - 12 IS - 1 A2 - , Y1 - 2007/02/01 UR - http://ebm.bmj.com/content/12/1/18.abstract N2 - Eussen SJ, de Groot LC, Joosten LW, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006;84:361–70.OpenUrlAbstract/FREE Full Text 
 
 Q In elderly people with mild vitamin B-12 deficiency and no to moderate cognitive impairment, does daily oral vitamin B-12 with or without folic acid for 24 weeks improve cognitive function? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Neurology ★★★★★☆☆ Geriatrics ★★★★☆☆☆ Design: randomised placebo controlled trial. Allocation: {concealed*}†. Blinding: blinded (participants, clinicians, {data collectors, and data analysts}†).* Follow up period: 24 weeks. Setting: 30 service flats and 24 care-facility homes in the Netherlands. Patients: 195 elderly people ⩾70 years of age (mean age 82 y, 76% women) who lived in the community or in care-facility homes. Exclusion criteria were history of cobalamin deficiency, receipt of cobalamin or folic acid supplements, surgery or diseases of the stomach or small … ER -