TY - JOUR T1 - Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee JF - Evidence Based Medicine JO - Evid Based Med SP - 81 LP - 81 DO - 10.1136/ebm.10.3.81 VL - 10 IS - 3 A2 - , Y1 - 2005/06/01 UR - http://ebm.bmj.com/content/10/3/81.abstract N2 - Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004;171:333–8.OpenUrlAbstract/FREE Full Text 
 
 Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD) solution more effective than topical vehicle control (VC) or placebo for providing symptom relief? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Rheumatology ★★★★★☆☆ Internal Medicine ★★★★★★★ Design: randomised vehicle and placebo controlled trial. Allocation: concealed.* Blinding: blinded (patients, healthcare providers, data collectors, and outcome assessors).* Follow up period: 28 days. Setting: 7 medical centres in Ontario, Canada. Patients: 248 patients who were 18–80 years of age (63% women, mean age 62 y) and had primary OA in ⩾1 knee (verified radiologically within the previous 6 mo) and at least moderate pain (identified with the Western Ontario and McMaster Universities [WOMAC] LK3.0 OA Index pain subscale). Exclusion criteria included secondary arthritis related to syphilitic … ER -