TY - JOUR T1 - QRISK underestimated risk of CVD in general practice patients; the Framingham score overestimated risk JF - Evidence Based Medicine JO - Evid Based Med SP - 123 LP - 123 DO - 10.1136/ebm.13.4.123 VL - 13 IS - 4 A2 - , Y1 - 2008/08/01 UR - http://ebm.bmj.com/content/13/4/123.abstract N2 - J Hippisley-CoxProfessor J Hippisley-Cox, University Park, Nottingham, UK; Julia.hippisley-cox@nottingham.ac.ukDoes the QRISK score predict risk of cardiovascular disease (CVD) in a validation sample of general practice patients? How does it compare with the Framingham score?Design:prospective cohort study.Setting:2 validation cohorts from general practices in the UK that provided routinely collected clinical data to 1 of 2 research databases (QRESEARCH, n = 160; THIN, n = 274).Patients:patients included in the THIN (n = 1.07 million) or QRESEARCH (n = 0.61 million) databases who were 35–74 years of age (51% women) and did not have diabetes or CVD and were not taking statins at baseline.Description of prediction guide:the QRISK score included traditional risk factors (age, sex, systolic blood pressure, smoking status, and total:high density lipoprotein serum cholesterol ratio) as well as social deprivation (Townsend score), family history of coronary heart disease in … ER -