TY - JOUR T1 - Once daily oral controller therapy with low dose theophylline or montelukast was not effective in poorly controlled asthma JF - Evidence Based Medicine JO - Evid Based Med SP - 115 LP - 115 DO - 10.1136/ebm.12.4.115 VL - 12 IS - 4 A2 - , Y1 - 2007/08/01 UR - http://ebm.bmj.com/content/12/4/115.abstract N2 - The American Lung Association Asthma Clinical Research Centers. Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. Am J Respir Crit Care Med 2007;175:235–42.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In patients with poorly controlled asthma while taking medication, what is the effectiveness of adding once daily oral controller therapy to low dose theophylline or montelukast? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Respirology ★★★★★★☆ Allergy & immunology ★★★★★☆☆ Design: randomised placebo controlled trial. Allocation: {concealed*}†. Blinding: blinded (clinicians, patients, {data collectors, outcome assessors, and data safety and monitoring committee}†).* Follow up period: 24 weeks. Setting: 19 American Lung Association Asthma Clinical Research Centres (ALA-ACRC) in the US. Patients: 489 patients ⩾15 years of age (mean age 40 y, 74% women, 61% white) who were diagnosed with asthma, were prescribed daily asthma medication for ⩾1 year, had FEV1 ⩾50% of the predicted value, and had poor asthma control (score ⩾1.5 on the Asthma Control Questionnaire [ACQ]). Patients continued their baseline medications. Exclusion criteria were use of oral corticosteroids, leukotriene antagonists, or theophylline within 4 weeks before randomisation; ⩾20 … ER -