TY - JOUR T1 - A low fat diet led to a minor weight loss at 7.5 years in postmenopausal women JF - Evidence Based Medicine JO - Evid Based Med SP - 109 LP - 109 DO - 10.1136/ebm.11.4.109 VL - 11 IS - 4 A2 - , Y1 - 2006/08/01 UR - http://ebm.bmj.com/content/11/4/109.abstract N2 - Howard BV, Manson JE, Stefanick ML, et al. Low-fat dietary pattern and weight change over 7 years: the Women’s Health Initiative Dietary Modification Trial. JAMA 2006;295:39–49.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In postmenopausal women, does a low fat diet lead to increased body weight over time? Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆ Design: randomised controlled trial (Women’s Health Initiative Dietary Modification Trial). Allocation: {concealed*}†. Blinding: blinded (outcome assessors, {data collectors, and data analysts}†).* Follow up period: mean 7.5 years. Setting: 40 clinical centres in the US. Participants: 48 835 women who were 50–79 years of age (mean age 62 y, 81% white), were postmenopausal, and consumed a diet with fat intake of ⩾32% of daily total calories. Exclusion criteria: previous breast cancer, cancers other than non-melanoma skin cancer in past 10 years, illness with predicted survival <3 years, and impediments to adherence (eg, alcoholism). Intervention: low fat dietary intervention (n = 19 541) or usual diet (n = 29 294). Women … ER -