TY - JOUR T1 - Vitamin E did not prevent cardiovascular disease and cancer in healthy women JF - Evidence Based Medicine JO - Evid Based Med SP - 11 LP - 11 DO - 10.1136/ebm.11.1.11 VL - 11 IS - 1 A2 - , Y1 - 2006/02/01 UR - http://ebm.bmj.com/content/11/1/11.abstract N2 - Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer. The Women’s Health Study: a randomized controlled trial. JAMA 2005;294:56–65.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In healthy women ⩾ 45 years of age, how effective is vitamin E in preventing cardiovascular disease (CVD) and cancer? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Design: randomised placebo controlled trial (Women’s Health Study [WHS], a randomised 2 × 2 factorial trial). Allocation: concealed.* Blinding: blinded {participants, healthcare providers, data collectors, and outcome assessors}†.* Follow up period: mean 10.1 years. Setting: {a mail-based trial in female health professionals in the US}†. Participants: 39 876 women ⩾45 years of age (mean age 55 y) without previous history of cancer (except non-melanoma skin cancer), CVD, or other major chronic illness; no history of adverse effects to aspirin; not taking aspirin or non-steroidal anti-inflammatory drugs more than once per week; not taking anticoagulants or corticosteroids; and not taking individual supplements of vitamin A, vitamin E, or β carotene more than once … ER -