TY - JOUR T1 - Review: viscosupplementation for knee osteoarthritis reduces pain and improves function JF - Evidence Based Medicine JO - Evid Based Med SP - 12 LP - 12 DO - 10.1136/ebm.11.1.12 VL - 11 IS - 1 A2 - , Y1 - 2006/02/01 UR - http://ebm.bmj.com/content/11/1/12.abstract N2 - Bellamy N, Campbell J, Robinson V, et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2005;(2):CD005321. 
 
 Q In patients with osteoarthritis of the knee, does viscosupplementation (with hyaluronan or hylan [HA]) relieve pain and improve physical function? Clinical impact ratings Rheumatology ★★★★★☆☆ Physical medicine & rehabilitation ★★★★★★☆ Data sources: Medline, EMBASE/Excerpta Medica, PREMEDLINE (to July 2003), Cochrane Central Register of Controlled Trials (Issue 2, 2003), and Current Contents (to September 2000); handsearches of relevant journals, conference proceedings (to April 2004), and reference lists; and consultation with industry representatives. Study selection and assessment: randomised controlled trials (RCTs), in any language, that assessed the use of viscosupplementation for treatment of osteoarthritis of the knee, compared with placebo or active treatment, and reported relevant outcomes. 2 reviewers independently assessed included trials for methodological quality using the Jadad scale. Outcomes: pain and physical function (assessed by the Western … ER -