TY - JOUR T1 - Review: a low clinical probability plus a normal D-dimer test result excludes a diagnosis of deep venous thrombosis JF - Evidence Based Medicine JO - Evid Based Med SP - 89 LP - 89 DO - 10.1136/ebm.10.3.89 VL - 10 IS - 3 A2 - , Y1 - 2005/06/01 UR - http://ebm.bmj.com/content/10/3/89.abstract N2 - Fancher TL, White RH, Kravitz RL. Combined use of rapid D-dimer testing and estimation of clinical probability in the diagnosis of deep vein thrombosis: systematic review. BMJ 2004;329:821.OpenUrlAbstract/FREE Full Text 
 
 Q In patients with suspected deep venous thrombosis (DVT), is a combination of rapid D-dimer testing with estimation of clinical probability accurate for excluding a diagnosis of DVT? Clinical impact ratings IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Emergency Medicine ★★★★★☆☆ Haematology ★★★★★☆☆ Data sources: Medline (1993–2003), Database of Abstracts and Reviews, and bibliographies of relevant articles. Study selection and assessment: prospective studies (published in English) that used a rapid D-dimer assay on at least a subgroup of consecutive outpatients with features of DVT; estimated the risk of DVT using a validated clinical probability tool that categorised patients as having low, intermediate, or high risk of DVT; evaluated outpatient data separately if inpatients were included; evaluated DVT data separately if patients with pulmonary embolism were included; had 100% patient follow up at ⩾3 months; documented DVT using ultrasonography, venography, or impedance plethsmography; and presented sufficient data for calculation of sensitivity and specificity of the D-dimer assay … ER -