TY - JOUR T1 - Tiotropium reduced exacerbations but not rate of FEV<sub>1</sub> decline in patients with COPD using other respiratory medications JF - Evidence Based Medicine JO - Evid Based Med SP - 43 LP - 43 DO - 10.1136/ebm.14.2.43 VL - 14 IS - 2 A2 - , Y1 - 2009/04/01 UR - http://ebm.bmj.com/content/14/2/43.abstract N2 - D P TashkinDr D P Tashkin, University of California, Los Angeles, Los Angeles, CA, USA; dtashkin@mednet.ucla.eduDesign:randomised placebo-controlled trial (Understanding Potential Long-Term Impacts on Function with Tiotropium [UPLIFT]). ClinicalTrials.gov NCT00144339.Allocation concealment:concealed.*Blinding:blinded (clinicians, patients, data collectors, and outcome adjudication committee).*Setting:490 centres in 37 countries worldwide.Patients:5993 patients ⩾40 years of age (mean age 65 y, 75% men) who had COPD, a history of ⩾10 pack-years of smoking, and postbronchodilation FEV1 ⩽70% of predicted and ⩽70% of FVC. Exclusion criteria included a history of asthma … ER -