TY - JOUR T1 - Topical chloramphenicol was not effective in children with acute infective conjunctivitis JF - Evidence Based Medicine JO - Evid Based Med SP - 18 LP - 18 DO - 10.1136/ebm.11.1.18 VL - 11 IS - 1 A2 - , Y1 - 2006/02/01 UR - http://ebm.bmj.com/content/11/1/18.abstract N2 - Rose PW, Harnden A, Brueggemann AB, et al. Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. Lancet 2005;366:37–43.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In children with acute infective conjunctivitis, is topical chloramphenicol effective for inducing clinical cure? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Infectious disease ★★★★★★☆ Paediatrics ★★★★★★☆ Design: randomised controlled trial. Allocation: concealed.* Blinding: blinded (patients, healthcare providers, data collectors, outcome assessors, and data analysts).* Follow up period: 7 days for the primary outcome plus an extra 5 weeks to assess relapse. Setting: 12 primary care practices in Oxfordshire, UK. Patients: 326 children 6 months to 12 years of age who had acute infective conjunctivitis. Exclusion criteria included an allergy to chloramphenicol, use of an antibiotic (current or within the previous 48 h), evidence of severe infection, and children who were immunocompromised. Intervention: 0.5% chloramphenicol (preservative free eye drops BP) (n = 163) or placebo (distilled water with the excipients boric acid, 1.5%, and borax, … ER -